Cognitive Dysfunction Contributes to Mobility Impairments in Huntington’s Disease

Cognitive Dysfunction Contributes to Mobility Impairments in Huntington’s Disease

BACKGROUND Huntington's disease (HD) is a progressive neurodegenerative disorder that results in a gradual decline in mobility and balance. Increasing evidence has documented an important role of executive function in the safe ambulation of the elderly and people with a variety of neurological disorders. Little is known about the contribution of cognitive deficits to decline in mobility over ti...

Applying Bioinfomatics Strategies in Huntingtons Disease Research

Cognitive impairments in Machado-Joseph disease.

BACKGROUND Cognitive function of Machado-Joseph disease (MJD) patients has not been clarified. OBJECTIVES To determine the characteristics of cognitive dysfunction in MJD patients and to assess the relationship of dysfunction to age at onset, age at examination, disease duration, education, ataxia, depression, anxiety, and CAG repeat length. DESIGN Case-control study. SETTING Research-ori...

Non Cognitive Neuropsychiatric Impairments in Alzheimer’s Disease

Methods: 131 patients with AD (mild, moderate degree) were included in the investigation according to the diagnostic criteria of DSM IV and MKB 10. 45 AD patients were on galantamine, 43-memantin and 43-combined therapy. The control group includes 45 patients. In our investigation in the main group of AD patients the duration of the disease was from 6 months to 4.3 years, on average 3.3 years. ...

Radiation- induced cognitive impairments

Introduction: Ionizing radiation is non-surgical treatment of brain tumors and metastases. Preclinical studies have showed main insights into harmful effects of radiation on the nervous system in vivo and in vitro. Cognitive impairment such as progressive memory, executive and attention performance deficits indicates a significant risk for patients experiencing conventional rad...